Fox is making another appointment with Best Medicine.
The network has renewed the dramedy starring Josh Charles for a second season in 2026-27. The pickup is not much a surprise, as Best Medicine has put up very solid ratings through its first season so far.
Additionally, The Hollywood Reporter has learned exclusively that Eliza Coupe (Happy Endings, The Residence) will guest star in the final two episodes of season one as an ex of Charles’ Dr. Martin Best.
“Best Medicine quickly became a breakout for us this season, blending sharp humor with real heart,” said Fox Television Network president Michael Thorn. “[Showrunner] Liz Tuccillo brings a distinctive creative voice to the series, and Josh Charles leads an exceptional cast that audiences have embraced. We, along with Propagate, are excited to build on that momentum in season two.”
Best Medicine is an adaptation of the long-running British series Doc Martin, with Charles playing a former top surgeon in Boston who leaves that life behind and becomes a general practitioner in a small fishing village where he spent his childhood summers. Abigail Spencer, Josh Segarra, Annie Potts and Cree also star.
The show has performed well for Fox this season, averaging 6 million cross-platform viewers over seven days. The Jan. 4 series premiere has accumulated 12.6 million viewers to date.
In the final episodes of season one, Coupe will play Dr. Eden Montgomery, who dated Martin during med school and for a few years after that. Her character is described as the female version of Martin: awkward and direct but self-confident and very intelligent. Now a fertility specialist, Eden comes to Port Wenn to help a patient and to win Martin back. Coupe is repped by Verve and Ames/Hashagan Entertainment.
Fox Entertainment Studios produces Best Medicine. Tuccillo executive produces with Ben Silverman, Rodney Ferrell and Howard T. Owens of Propagate Content (which brought the Doc Martin format to the U.S.) and Doc Martin EPs Mark Crowdy and Philippa Braithwaite.
